The benchmark S&P BSE Sensex snapped its 2-day gains by declining 50 points in the early trade due to fresh selling, mainly in consumer durables, capital goods, refinery and healthcare sectors in view of lower global cues.
The Sensex resumed lower at 22,488.96 and hovered in a range of 22,532.82-22,455.49 before quoting at 22,458.91 at 1000 hours (IST).
The NSE 50-share Nifty also moved down by 10.15 points to 6,705.15.
Major losers were Bharti Airtel (1.19 pct), Hindalco Ind (1.01 pct), HDFC (0.94 pct), Tata Steel (0.80 pct), ICICI Bank (0.76 pct) and Maruti Suzuki (0.71 pct).
Key benchmark indices in Japan, Hong Kong, China, Singapore, South Korea and Taiwan were down by 0.44 pct to 2.3 pct.
US stocks fell broadly on Tuesday after disappointing earnings amidst a slide in Twitter shares.